Total synthesis of (±)-leuconolam: intramolecular allylic silane addition to a maleimide carbonyl group
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منابع مشابه
Total synthesis of (±)-leuconolam: intramolecular allylic silane addition to a maleimide carbonyl group.
A concise total synthesis of the plant alkaloid (±)-leuconolam (1) has been achieved. A regio- and diastereoselective Lewis-acid mediated allylative cyclization was used to establish, simultaneously, two adjacent tetrasubstituted carbon centers. Furthermore, an essential arene cross-coupling to a hindered haloalkene was enabled by the use of a novel 2-anilinostannane.
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2013
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c3sc00056g